list biological laboratories公司是世界的科研毒素試劑供應商，其毒素包括霍亂病毒，蛇毒，百日咳毒素等各類毒素,我公司常年低價供應,貨期快.有意者請. 百日咳毒素長期現貨供應，貨號181及180。
list biological 758A
一種主要的醫院病原體，艱難梭菌（Clostridium difficile）引起抗生素相關性結腸炎和腸道炎癥性疾病，一起稱為CDI。
C艱難梭菌毒素如何引起腹瀉？ 通過釋放兩種大蛋白腸毒素，艱難梭菌毒素A（TcdA）和艱難梭菌毒素B（TcdB），艱難梭菌介導炎性腹瀉并損害腸??上皮細胞。施用于培養細胞時的毒素都會破壞細胞骨架并引發細胞凋亡依賴性細胞凋亡，盡管艱難梭菌毒素B的效力比艱難梭菌多很多倍。毒素A.兩種毒素還激活腸上皮細胞和免疫細胞以產生細胞因子和趨化因子，可能導致與嚴重CDI相關的并發癥。TcdA和TcdB的細胞內靶標是RhoGTP酶，其調節許多宿主細胞過程，包括建立上皮屏障和免疫細胞的遷移和信號傳導。當Rho蛋白被艱難梭菌毒素A或B 糖基化時，信號被破壞，導致CDI的腸損傷和炎癥特征。
List Labs C. Difficile Toxins參與了診斷的研究和開發。
抗艱難梭菌二元毒素B亞基（雞lgY）
產品＃和尺寸
＃758A（0.1毫克） - 320.00美元
艱難梭菌是引起抗生素相關性腹瀉和假膜性大腸桿菌的病原體。
1，2它產生兩種主要的外毒素(毒素A和毒素B)。
大型梭狀細胞毒素科。一些艱難梭菌還產生一種二價ADP-核糖化毒素(CDT)，這種毒素可以修飾actin3 CDT二元毒素在疾病誘導中的致病作用 艱難梭菌的ED尚不清楚，但從結腸炎患者中分離出的約10%的菌株含有CDT二元毒素基因。
4，5艱難梭菌A和B為高分子量葡糖基轉運體。 抑制GTPases Rho家族成員的rase。毒素A被稱為腸毒素，分子量為300 kDa，等電點為5.3。毒素B，被稱為細胞毒素， 分子量為270 kDa，pl為4.1。毒素A和毒素B通過蘇氨酸殘基的葡萄糖化使Rho、RAC和Cdc 42等小GTPase失活。6，7，8抑制這些GTPase S導致信號轉導級聯的關閉，導致細胞骨架的解聚，某些應激激活蛋白激酶的基因轉錄，磷脂合成的下降。
Ylinositol 4，5二磷酸甚至可能導致細胞極化的喪失9細胞骨架結構的喪失導致細胞的四舍五入，這種結構的喪失可能是宿主對C的反應的原因。 艱難。毒素A和B所針對的GTP酶與許多細胞反應有關，但這些毒素具有不同的生理效應。這兩種毒素都會刺激皮膚，增加維生素A。 [10]只有毒素A在上皮細胞表面有一個結合位點，即碳水化合物11，這可能與兔回腸的劇烈反應有關。23，
13毒素B是一種p型毒素。 組織培養中哺乳動物細胞的細胞毒素14，
15毒素B在細胞四舍五入中的毒性至少是毒素A的1000倍。通過抑制信號轉導級聯，毒素A 毒素B可以阻斷下游的反應。毒素A可誘導白介素8.
16毒素B可能阻斷5-羥色胺的釋放，
17以及刺激磷脂的產生 ESC和D.
18，19由于具有影響細胞骨架解聚的能力，毒素B被證明能抑制雙相肌肉收縮。
20艱難梭菌毒素A和B有63%的同源性。 每種毒素的C-末端第三位都是由被稱為梭狀重復寡肽(作物)的高度序列組成。 Y抗原。其余的N端三分之二的毒素A和B在序列同源性方面不太相似，但每種蛋白質的這一部分都含有葡萄糖。
22，23 CDT二元毒素是ADP-核糖轉移酶家族(ADPRT)的成員。3 CDT二元毒素與C.肉毒桿菌C2毒素同屬于AB二元毒素亞家族。 產氣莢膜的毒素。
24該二元毒素由兩個獨立產生的組分組成，即酶組分A亞基CdtA(48 KD)和結合和易位復合物。 Nent B亞基CdtB(94 KD)介導CdtA細胞的進入。
25 cdt二元毒素引起肌動蛋白細胞骨架的解聚和微管基膜突起的形成。
[26]CDT二價毒素B亞基cdtB是cdtA進入TH的必需物質。26 CDT二進毒素cdtB亞基cdtB參與了高致病性艱難梭菌的粘附和定植。
27 CdtB組分必須通過切割激活，然后在細胞表面形成七肽，并與特定的細胞表面受體結合。細胞表面受體已被識別 28隨后，CdtA與CdtB結合，通過受體介導的內吞作用進入細胞。cdtA的N端與INTERA有關。 在cdtB作用下，C端含有酶活性。29根據lota毒素的活性，預測cdp-核糖單聚體G-actin在arg 17上將不可逆轉。 7殘留。這種ADP-核糖基化將阻止G-肌動蛋白與F-肌動蛋白的聚合，破壞F-actin：G-actin的平衡，從而導致細胞的四舍五入和細胞死亡。
產品僅用于研究目的，不用于人類或診斷劑。
貨號 | 品名 | 規格 | 價格 |
list104 | Cholera Toxin B Subunit (Choleragenoid) in low salt1 | 0.5mg | 4930 |
list106 | Cholera Toxin B Subunit Fluorescein Isothiocyanate Conjugate (BFITC) | 0.2mg | 9775 |
list112 | Cholera Toxin B Subunit Biotin | 0.2mg | 9775 |
list122 | Enterotoxin Type B from Staphylococcus aureus1,3 | 0.5mg | 7225 |
list123 | Enterotoxin Type B Toxoid from Staphylococcus aureus 1,3 | 0.25mg | 8075 |
list139 | Botulinum Neurotoxin Type B Toxoid | 10µg | 6800 |
list150 | Diphtheria Toxin, unnicked from Corynebacterium diphtheriae | 1mg | 11050 |
list151 | Diphtheria Toxoid, from Corynebacterium diphtheriae | 0.5mg | 10625 |
list153 | Toxin A Toxoid from Clostridium difficile | 100µg | 11900 |
list156 | Pasteurella Multocida Toxin | 50µg | 8075 |
list160 | Exotoxin A from Pseudomonas aeruginosa | 1mg | 4420 |
list161 | Shiga Toxin 1 from Escherichia coli1,4,8 | 10µg | 11900 |
list162 | Shiga Toxin 2 from Escherichia coli1,4,8 | 10µg | 11050 |
list174 | Anthrax Protective Antigen, Activated (PA 63) from Bacillus anthracis | 0.5mg | 9350 |
list175 | Anthrax PA 63 - Fluorescein Isothiocyanate Conjugate (PAFITC) | 50µg | 7225 |
list180 | Pertussis Toxin Islet-Activating Protein Lyophilized in buffer | 50µg | 5525 |
list181 | Pertussis Toxin Islet Activating Protein Lyophilized (Salt-Free) | 50µg | 5525 |
list184 | Pertussis Toxin Mutant | 50µg | 5525 |
list186 | FIMBRIAE 2/3 from B. pertussis | 50µg | 5950 |
list187 | Pertactin from Bordetella pertussus (69 kDa Protein) | 50µg | 4590 |
list193 | Tetanus Toxin C Fragment | 10µg | 9350 |
list201 | LPS from Escherichia coli O111:B4 | 5mg | 3230 |
list206 | LPS, Escherichia coli 0157:H7 | 10.0mg | 4760 |
list225 | LPS from Salmonella typhimurium | 5mg | 2890 |
list301 | LPS from Escherichia coli J5 (Rc) | 5mg | 2890 |
list302 | LPS from Escherichia coli K12, D31m4 (Re) | 5mg | 2890 |
list304 | LPS from Salmonella minnesota R595 (Re) | 5mg | 2890 |
list314 | LPS from Escherichia coli K12 strain LCD25 | 1mg | 2890 |
list400 | HPT™ LPS, highly purified from Bordetella Pertussis 165 | 1mg | 5100 |
list401 | Lipid A monophosphoryl from Salmonella minnesota R595 | 1mg | 3400 |
list421 | Ultra Pure LPS from Escherichia coli O111:B4 | 1mg | 3570 |
list423 | Ultra Pure LPS from Escherichia coli O55:B5 | 1mg | 3570 |
list433 | LISTÔ HPTÔ, LPS, highly purified Escherichia coli O113 LPS | 1mg | 4080 |
list434 | Ultra Pure LPS from Salmonella minnesota R595 (Re) | 1mg | 3400 |
list520 | SNAPtide® Peptide Substrate (o-Abz/Dnp) (U.S. Patent #6,504,006) | 200nmoles | 9775 |
list521 | SNAPtide® Peptide Substrate (FITC/DABCYL) (U.S. Patent #6,504,006) | 200nmoles | 8500 |
list523 | SNAPtideÒ Peptide Substrate flP6 (DABCYL/5-IAF), U.S. Patent Pending #61/252,675 | 200nmoles | 8500 |
list525 | Control Peptide for SNAPtideÒ #520 | 200nmoles | 8500 |
list526 | Control Peptide for SNAPtide® #521 | 200nmoles | 8500 |
list528 | Unquenched Calibration Peptide for SNAPtide® 521 | 50nmoles | 2890 |
list529 | Unquenched Calibration Peptide for SNAPtide® 520 | 50nmoles | 2890 |
list530 | MAPKKide® Peptide Substrate (o-Abz/Dnp) | 200nmoles | 5100 |
list531 | MAPKKide® Peptide Substrate (DABCYL/FITC) | 200nmoles | 5100 |
list532 | MAPKKide® Plus (AMC) Specific Substrate for Anthrax Lethal Factor | 100nmoles | 4250 |
list539 | Unquenched Calibration Peptide for MAPKKideÒ 530 | 50nmoles | 2890 |
list540 | VAMPtide® Peptide Substrate (o-Abz/Dnp) | 200nmoles | 8500 |
list541 | VAMPtide® Peptide Substrate (FITC/DABCYL) | 200nmoles | 8500 |
list542 | VAMPtide® Peptide Substrate (PL 150, Pya/Nop) | 200nmoles | 8500 |
list549 | Calibration Fluorophore for VAMPtideÒ 540 | 100nmoles | 2890 |
list550 | SNAP Etide® Peptide Substrate (o-Abz/Dnp) | 100nmoles | 6800 |
list560 | SYNTAXtideÒ Peptide Substrate (o-Abz/Dnp) for C. botulinum Type C | 200nmoles | 8500 |
list703 | Anti-Cholera Toxin B Subunit (Goat) | 0.1ml | 3060 |
list752 | Anti-Toxin A from Clostridium difficile (Goat) | 0.5ml | 3230 |
list760 | Anti-Exotoxin A (Goat) | 0.5ml | 3400 |
list781 | Anti-Protective Antigen from Bacillus anthracis (Goat) affinity purified, Liquid6,7 | 0.1mg | 7055 |
list100B | Cholera Toxin (Azide Free)1 | 1mg | 3400 |
list101B | Cholera Toxin1 | 1mg | 3400 |
list101C | Cholera Toxin1 | 2mg | 5355 |
list116L | Alpha Toxin from C. septicum4,6,7 | 50µg | 4930 |
list126A | Epsilon Toxin from C. perfringens1,4,8 | 0.1mg | 5950 |
list128A | Botulinum Neurotoxin Type A Complex from Clostridium botulinum1,3 | 10µg | 2890 |
list128C | Botulinum Neurotoxin Type A Complex from Clostridium botulinum1,3 | 100µg | 5440 |
list130A | Botulinum Neurotoxin Type A from Clostridium botulinum1,3 | 10µg | 5440 |
list130B | Botulinum Neurotoxin Type A from Clostridium botulinum1,3 | 100µg | 13600 |
list133L | Botulinum Neurotoxin Type A Toxoid, Liquid6,7 | 10µg | 5440 |
list136A | Botulinum Neurotoxin Type B. from Clostridium botulinum 1,3 | 10µg | 5100 |
list136B | Botulinum Neurotoxin Type B, from Clostridium botulinum1,3 | 100µg | 17000 |
list138A | Botulinum Neurotoxin Type B Complex, Nicked, from Clostridium botulinum1,3 | 10µg | 2890 |
list138B | Botulinum Neurotoxin Type B Complex, Nicked, from Clostridium botulinum1,3 | 100µg | 7225 |
list140A | Botulinum Neurotoxin Type E, Nicked, Complex from Clostridium botulinum1,3 | 10µg | 2890 |
list140B | Botulinum Neurotoxin Type E, Nicked, Complex from Clostridium botulinum1,3 | 100µg | 8925 |
list141A | Botulinum Neurotoxin Type E, Nicked, from Clostridium botulinum1,3 | 10µg | 8075 |
list146A | Botulinum Neurotoxin Type D, Nicked, Recombinant from Clostridium botulinum1,3 | 10µg | 5355 |
list149A | Diphtheria Toxin CRM Mutant | 0.25 mg | 8500 |
list152C | Toxin A from Clostridium difficile | 100µg | 9010 |
list154A | Toxin B Toxoid from Clostridium difficile | 20µg | 2890 |
list15 | Toxin B from Clostridium difficile | 2µg | 2890 |
list155B | Toxin B from Clostridium difficile | 20µg | 8500 |
list155C | Toxin B from Clostridium difficile | 200µg | 15300 |
list155L | Toxin B from Clostridium difficile, Liquid6,7 | 50µg | 9860 |
list157A | Binary Toxin from Clostridium difficile, A Subunit | 20µg | 5950 |
list158A | Binary Toxin from Clostridium difficile, B Subunit | 40µg | 5950 |
list159A | Glutamate Dehydrogenase (GDH) from Clostridium difficile6,7 | 0.1mg | 4930 |
list169A | Anthrax Lethal Factor (LF-A) , Recombinant from Bacillus anthracis Native Sequence | 0.1mg | 3060 |
list169B | Anthrax Lethal Factor (LF-A),Recombinant from Bacillus anthracis Native Sequence | 1mg | 12750 |
list169L | Anthrax Lethal Factor (LF-A),Recomb.from Bacillus anthracis 5,7 | 0.2 mg | 5950 |
list171E | Anthrax Protective Antigen (PA), Recombinant from Bacillus anthracis | 0.5mg | 8755 |
list172B | Anthrax Lethal Factor (LF), Recombinant from Bacillus anthracis | 1mg | 12750 |
list172C | Anthrax Lethal Factor (LF), Recombinant from Bacillus anthracis | 10mg | 39525 |
list172L | Lethal Factor, Recomb from Bacillus anthracis, froz liq 5,7 | 1.0 mg | 12750 |
list173B | Anthrax Edema Factor (EF), Recombinant Mutant S447N from Bacillus anthracis | 0.5mg | 16150 |
list176A | Anthrax Lethal Factor (LF), Recombinant, Mutant E687C from Bacillus anthracis | 0.1mg | 5100 |
list176B | Anthrax Lethal Factor (LF), Recombinant, Mutant E687C from Bacillus anthracis | 1mg | 16150 |
list177A | Anthrax Protective Antigen Fragment (PA 20) from Bacillus anthracis | 50µg | 5950 |
list177B | Anthrax Protective Antigen Fragment (PA 20) from Bacillus anthracis | 0.25mg | 11050 |
list178A | Anthrax Edema Factor (EF), Recombinant from Bacillus anthracis | 0.1mg | 2890 |
list179A | Pertussis Toxin Islet Activating Protein (in glycerol)6,7 | 50µg | 4845 |
list188L | Adenylate Cyclase Toxin from B. pertussis, Recombinant, Frozen Liquid5,7 | 50µg | 5270 |
list190A | Tetanus Toxin2 | 25µg | 2890 |
list190B | Tetanus Toxin2 | 100µg | 9350 |
list191A | Tetanus Toxoid | 25µg | 4675 |
list191B | Tetanus Toxoid | 100µg | 13600 |
list196A | C-fragment, FITC Conjugate | 10µg | 6800 |
list203A | LPS, Escherichia coli O55:B5 | 2.5 mg | 3060 |
list500A | SNAP-25 Recomb Protein Substrate for C. botulinum Type A and E Neurotoxin | 100µg | 5525 |
list510A | GST Synaptobrevin-2 Protein Recomb. Protein Substrate for C. botulinum Type B,D and F | 100µg | 5950 |
list610A | Botulinum Neurotoxin Type A Light Chain, Recombinant1 | 10µg | 4760 |
list611A | Botulinum Neurotoxin Type A Light Chain, GST Fusion, Recombinant1 | 15µg | 4760 |
list612A | Botulinum Neurotoxin Type A Heavy Chain, Recombinant, Binding Domain1 | 50µg | 4760 |
list613A | Botulinum Neurotoxin Type A Heavy Chain, Recombinant, Binding Domain, GST Fusion1 | 50µg | 4760 |
list620A | Botulinum Neurotoxin Type B Light Chain, Recombinant1 | 10µg | 8500 |
list622A | Botulinum Neurotoxin Type B Heavy Chain, Recombinant, Binding Domain1 | 50µg | 4760 |
list623A | Botulinum Neurotoxin Type B Heavy Chain, Recombinant, Binding Domain, GST Fusion1 | 50µg | 4760 |
list62 | Botulinum Neurotoxin Type C Light Chain, Recombinant1 | 10µg | 8500 |
list630A | Botulinum Neurotoxin Type D Light Chain, Recombinant1 | 10µg | 5695 |
list650A | Tetanus Toxin Light Chain, Recombinant | 10µg | 3825 |
list690B | Receptor for C. botulinum Type A Neurotoxin GST-SV2c luminal domain | 100nmoles | 6800 |
list730A | Anti-Botulinum Neurotoxin, Type A (Chicken lgY), Liquid6,7 | 0.1mg | 5610 |
list731L | Anti-Botulinum Neurotoxin, Type A (Mouse lgG monoclonal F1-40), Liquid6,7 | 0.1mg | 5950 |
list736A | Anti-Botulinum Type B (Chicken lgY), Liquid6,7 | 0.1mg | 5950 |
list753A | Anti-Clostridium difficile Toxin A (Chicken lgY), Liquid6,7 | 0.1mg | 5780 |
list754A | Anti-Clostridium difficile Toxin B (Chicken lgY), Liquid6,7 | 0.1mg | 5780 |
list756A | Anti-Clostridium difficile Glutamate Dehydrogenase, lgY, Liquid6,7 | 0.1mg | 5780 |
list757A | Anti-Clostridium difficile Binary Toxin A subunit (Chicken lgY), Liquid6,7 | 0.1mg | 5780 |
list758A | Anti-Clostridium difficile Binary Toxin B subunit (Chicken lgY), Liquid6,7 | 0.1mg | 5780 |
list759A | Biotinylated Anti-Clostridium difficile Binary Toxin B subunit (Chicken lgY), Liquid6,7 | 0.1mg | 5780 |
list761L | Anti-Shiga Toxin 1 (Rabbit), lgG, Liquid6,7 | 0.5mg | 3400 |
list765L | Anti-Shiga Toxin 2 (Rabbit), IgG, Liquid6,7 | 0.5mg | 2890 |
list766L | Anti-Shiga Toxin, Camelid Antibody, VHH, Liquid6,7 | 0.5mg/ml | 5950 |
list768L | Biotinylated Anti-Lethal Factor from B. anthracis, IgY, Liquid6,7 | 0.1mg | 5950 |
list769B | Anti-Lethal Factor from Bacillus anthracis (Chicken lgY), Liquid6,7 | 0.2mg | 8500 |
list771B | Anti-Protective Antigen from Bacillus anthracis (Goat) | 1mg | 2890 |
list772B | Anti-Lethal Factor from Bacillus anthracis (Goat) | 1.0 mg | 2890 |
list773L | Anti-Edema Factor from Bacillus anthracis (Goat), Liquid6,7 | 1mg | 2890 |
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